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BhattaraiYWilliamsBBBattaglioliEJWhitakerWRTillLGroverMet alGut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion

Injection minimizes enzymatic degradation and provides measurable, repeatable plasma and tissue concentrations in research animals

Depending on the treatment objective, it can be administered through subcutaneous injections, oral capsules or drops, food-derived, or topical application

It is derived from a protein sequence originally identified during research involving gastric proteins, leading scientists to investigate its biological properties under controlled laboratory conditions

If confirmed bioavailability is 20%+ below baseline, either increase the dose proportionally (if toxicity margins allow) or revert to a less-masked formulation and accept the trade-off